Top plays from NFL Week 15: 49ers lead Seahawks 21-6 on TNF FOOTBALL NATIONAL LEAGUE 49ERS HOLD 21-6 LEAD OVER SEAHAWKS ON TNF IN NFL WEEK 15 TOP PLAYS

Dec. 11, 2022, Santa Clara, California, USA: In the third quarter of a game between the San Francisco 49ers and the Tampa Bay Buccaneers at Levi's Stadium, quarterback Brock Purdy (13), of the San Francisco 49ers, looks to the sideline before running a play. Mandatory Credit: USA TODAY Sports' Cary Edmondson

USA TODAY Sports' Cary Edmondson

 On Thursday Night Football in Week 15 of the NFL season, Geno Smith and the Seattle Seahawks welcome the Brock Purdy-led San Francisco 49ers to Seattle.

Brock Purdy, a rookie quarterback for the San Francisco 49ers, is anticipated to start his second NFL game on Thursday against the Seattle Seahawks, according to ESPN.

Due to rib and oblique ailments, Purdy was only able to participate in a small amount of practise sessions during the entire week. He was hurt during Sunday's 35-7 rout of the Tampa Bay Buccaneers against the San Francisco 49ers.

Against the Buccaneers, Purdy completed 16 of his 21 throws for 185 yards and two touchdowns. He also ran for a score for San Francisco (9-4), which, with a victory over Seattle (7-6) on Thursday night, will claim the NFC West title.

In the 2022 NFL Draft, Purdy, age 22, was chosen with the last overall pick, earning him the moniker "Mr. Irrelevant." the Field Level

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Injuries to starter Trey Lance and backup quarterback Jimmy Garoppolo have forced Purdy, the final pick in this year's draught, into the starting lineup. Smith, who is leading the NFL with a 71.5 completion percentage this season, has been one of the biggest surprises in the NFL.

The top plays are listed below!

According to ESPN analyst Adam Schefter, rookie quarterback Brock Purdy is anticipated to start for the 49ers against the Seahawks in Seattle on Thursday despite rib and oblique ailments. What you need to know is as follows:

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In the team's Week 14 victory over the Buccaneers, Purdy, filling in for the injured Jimmy Garoppolo, completed 16 of 21 passes for 185 yards and two touchdowns while also scoring once on the ground.

After a great career at Iowa State, the 49ers selected Purdy with the final pick of the 2022 NFL Draft (262nd overall).

In the NFC West, San Francisco (9-4) leads Seattle (7-6) by two games. The Seahawks are currently seventh, one position outside the NFC postseason picture, while the 49ers are third.

The Seattle Seahawks will try to stay alive in the NFC West title race when they host the rival San Francisco 49ers on Thursday Night Football. After losing three out of their last four games to fall out of the divisional lead, the Seahawks (7-6) need a victory to avoid being eliminated from the divisional title. A win would also help their wild card hopes since they enter Week 15 behind the Commanders and Giants (both 7-5-1) for the final spot in the NFL playoff picture. Meanwhile, the 49ers (9-4) can become the first team in the NFL to clinch a division this season with a victory on TNF.

Kickoff is set for 8:15 p.m. ET. San Francisco is a three-point favorite in the latest Seahawks vs. 49ers odds from Caesars Sportsbook, while the over/under for total points scored is 43. Before making any 49ers vs. Seahawks picks or NFL predictions, you'll want to see what SportsLine's resident Seahawks expert, Josh Nagel, has to say.

With more than 20 years of experience in the sports betting market, Nagel is a Nevada-based handicapper. The associate managing editor of SportsLine has won multiple sports betting competitions and has covered the gambling sector on a number of platforms. Since the start of the 2016 season, he has hit 749-636-22 or 54% of his NFL picks against the spread.

Santa Clara, California - December 11: San Francisco 49ers' Brock Purdy, No. 13, celebrates the score. [+] AGORA IMAGES

Additionally, in his previous 25 choices against the spread featuring the Seahawks, Nagel has a 19-6 record. Everyone who has followed him is very successful.

Nagel has recently decided on his picks and TNF predictions after focusing on the Seahawks vs. 49ers game. To view Nagel's picks, go to SportsLine. Here are some NFL odds and wagering lines for the Niners vs. Seahawks matchup.

- 49ers versus. Seahawks point spread: San Francisco -3

- 49ers at Seahawks over/under: 43 pts

- Money line for the 49ers versus. Seahawks: San Francisco -180, Seattle +150

- SF: 49ers' scoring defence is the best in the league (15.2 points per game).

- SEA: LB In terms of tackles, Jordyn Brooks is second in the NFL (141).

- 49ers vs. Seahawks predictions: View predictions at SportsLine

The 49ers' ability to cover

On the point total, we can tell you that Nagel is leaning Under, but he has also identified a crucial X-factor that has him betting heavily on one side of the spread. Only at SportsLine is he disclosing what it is and which side to support.

NFL regular season questions: Will Tom Brady continue his postseason streak? Miami to finish the year?

The NFL's 2022 season was the most competitive one in league history. In fact, 158 games have been tied at one point entering the fourth quarter, which is a record for the first 14 weeks of an NFL season. There are many important problems that need to be resolved before the playoffs begin because there is such little distance in the standings between the majority of the league with only four games remaining.

Here are ten of the league's most pressing questions and potential future developments for the remainder of the 2022 season and beyond.

Will we ever see Aaron Rodgers again?

Aaron Rodgers famously described his future in football as a "wonderful mystery," but the two-time defending NFL MVP has 58.3 million reasons to play for the Green Bay Packers again in 2023. A guaranteed option for that significant sum of $58.3 million was included in his $150 million, three-year agreement that he signed in the summer.

It would be incredible to see him turn down that money and the chance to team up with Christian Watson, the receiver the Packers selected with the 34th overall pick in the 2022 NFL Draft, who is growing quickly. The 6-4, 208-pound wideout, who finished sixth in the NFL this season with seven receiving touchdowns grabbed in the last four games, ran a 4.36 40-yard dash at the combine.

Visit SportsLine right away to find out from the professional who is 19-6 in his past 25 against-the-spread predictions involving Seattle which side of the 49ers vs. Seahawks spread to back.